https://eraslab.gxmuyfy.cn/tag/%E5%8F%91%E6%98%8E%E4%B8%93%E5%88%A9/ 发明专利 Hugo Blox Builder (https://hugoblox.com)en-usTue, 28 Jun 2022 00:00:00 +0000 https://eraslab.gxmuyfy.cn/media/logo_hu_2ee990db4a8735f3.png https://eraslab.gxmuyfy.cn/tag/%E5%8F%91%E6%98%8E%E4%B8%93%E5%88%A9/ https://eraslab.gxmuyfy.cn/achievements/patents/2022-06-28-hcc-biomarker-patent/ Tue, 28 Jun 2022 00:00:00 +0000 https://eraslab.gxmuyfy.cn/achievements/patents/2022-06-28-hcc-biomarker-patent/ <p>2022年4月， 实验室团队肝胆外科方向彭涛教授等获授权国家发明专利《一种用于原发性肝细胞癌早期诊断的生物标志物及其检测试剂的应用》，该发明提供了一种用于原发性肝细胞癌早期诊断的生物标志物及其检测试剂和应用，属于肝癌诊断技术领域。该发明通过16S rRNA测序的方法对检测对象的粪便标本提取细菌DNA后进行Illumina Miseq测序，鉴定出肝癌早期和健康对照的肠道生物标志物，并通过生物标志物建立特异性鉴定肝癌早期和健康人群样本的随机森林模型，绘制学习曲线评估模型的拟合情况，通过接受者操作特性曲线评估模型效果；预测模型的曲线下面积为0.95，测试结果的精度为0.97，召回率为1.0，特异度为0.98。因此，该发明的生物标志物、构建的随机森林训练模型和检测方法对肝癌早期诊断具有良好的市场前景，对肝癌诊断方案的改进具有重要意义。</p> <p> <figure > <div class="d-flex justify-content-center"> <div class="w-100" ><img alt="" srcset=" /achievements/patents/2022-06-28-hcc-biomarker-patent/1_hu_8d82056c01a3702b.webp 400w, /achievements/patents/2022-06-28-hcc-biomarker-patent/1_hu_130bdb73a6710e0a.webp 760w, /achievements/patents/2022-06-28-hcc-biomarker-patent/1_hu_8c3c427d75677e43.webp 1200w" src="https://eraslab.gxmuyfy.cn/achievements/patents/2022-06-28-hcc-biomarker-patent/1_hu_8d82056c01a3702b.webp" width="537" height="760" loading="lazy" data-zoomable /></div> </div></figure> <figure > <div class="d-flex justify-content-center"> <div class="w-100" ><img alt="" srcset=" /achievements/patents/2022-06-28-hcc-biomarker-patent/2_hu_6895e85f5fe84319.webp 400w, /achievements/patents/2022-06-28-hcc-biomarker-patent/2_hu_e5c58cb68f9eec3f.webp 760w, /achievements/patents/2022-06-28-hcc-biomarker-patent/2_hu_8b33992d9ca7579c.webp 1200w" src="https://eraslab.gxmuyfy.cn/achievements/patents/2022-06-28-hcc-biomarker-patent/2_hu_6895e85f5fe84319.webp" width="537" height="760" loading="lazy" data-zoomable /></div> </div></figure> </p>